COMPARISON OF THE EFFECTS OF EIGHT WEEKS OF RESISTANCE TRAINING WITH AND WITHOUT SAFFRON EXTRACT, BARBERRY ON SERUM LEVEL 4 OF RETINOL BINDING PROTEIN, AND INSULIN RESISTANCE IN OBESE MICE WITH HIGH-FAT DIET

Background: The purpose of this study was to compare the effect of eight weeks of resistance training with and without the use of aqueous extracts of barberry and saffron on serum levels of RBP4, glucose, insulin and insulin resistance in obese mice. Methods: In this study, 80 mice with a mean weight of 41± 2 g were exposed to high fat diet for 10 weeks. Then, they were randomly assigned to 8 resistance training groups (10 n), resistance and saffron (10 n), saffron (10= n ), Resistance and barberry (n =10), barberry (n =10), saffron and barberry (10n =), resistance training with extract of saffron and barberry (10n =) and control group (n = 10). The resistance training program included raising the mice from the ladder with weight (three sets and 5 repetitions each) three times a week for 8 weeks. The consumption of saffron and barberry extracts was done at 0.08 for total weight of mice for 8 weeks. After 14 hours of fasting, the initial blood sample was taken at 5 ml of the left ventricle of the rats and RBP4, glucose, insulin and insulin resistance levels were measured. One-way analysis of variance was used to compare the data between groups. All calculations were considered at P≤0.05 Results: The results showed that there was a significant difference in the levels of RBP4 (P = 0.002), glucose (P = 0.03), insulin (P = 0.02), and insulin resistance (P= 0.004) There are different research groups. Follow-up test results showed that RBP4 levels decreased in the resistance training group compared to the barberry and control groups. In saffron group, resistance to barberry and control group decreased. The saffron group also decreased compared to the saffron and barberry training groups. Conclusion: The findings of this study emphasize the effect of resistance training, the use of saffron extract and barberry extract on reducing the metabolic effects of obesity by reducing RBP4 and reducing glucose, insulin and insulin resistance.